反应详情

To a suspension of 9H-carbazole-1-carboxylic acid (148 mg) and 1-hydroxybenzothiazole (114 mg) in dichloromethane (3 ml) was added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (201 mg) and the mixture was stirred for 15 minutes. After adding 3-(1,2,4-triazol-1-yl)aniline (123 mg) and 4-dimethylaminopyridine (128 mg), the mixture was stirred for 24 hours. The mixture was evaporated under reduced pressure and purified by a silica gel column chromatography eluting with 2% methanol in dichloromethane to give N-[3-(1,2,4-triazol-1-yl)-phenyl]-9H-carbazole-1-carboxamide (103 mg, 41.5%).

1. stirringthe mixture was stirred for 24 hours
2. customThe mixture was evaporated under reduced pressure
3. custompurified by a silica gel column chromatography
4. washeluting with 2% methanol in dichloromethane