反应详情

To a suspension of 9H-carbazole-1-carboxylic acid (112 mg) and 3-(1,3,4-triazol-1-yl)aniline (147 mg) in dichloromethane (3 ml) were added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (188 mg) and 4-dimethylaminopyridine (43 mg). The mixture was stirred at ambient temperature for 24 hours and diluted with dichloromethane. The solution was washed with water and brine, dried over magnesium sulfate and evaporated under reduced pressure. The residue was triturated with methanol. The resulting precipitate was collected by filtration and dried to give N-(3-([1,2,4]triazol-4-yl)phenyl)-9H-carbazole-1-carboxamide (38 mg, 15.4%).

1. washThe solution was washed with water and brine
2. dry with materialdried over magnesium sulfate
3. customevaporated under reduced pressure
4. customThe residue was triturated with methanol
5. filtrationThe resulting precipitate was collected by filtration
6. customdried