反应详情

温度

-60 °C

To a suspension of 2,2′-bithiophene (1.0 g) in tetrahydrofuran (10 ml) was added a solution of n-butyl lithium in n-hexane (1.54 M, 4.3 ml) at −25° C. under nitrogen atmosphere. The mixture was stirred at −60° C. for 30 minutes. To the solution dry-ice (1.0 g) was added and the mixture was stirred at ambient temperature for 30 minutes. To the resultant suspension hydrochloric acid (1N, 10 ml) and ethyl acetate were added. The separated organic layer was washed with brine, dried over magnesium sulfate and evaporated under reduced pressure. The residue was triturated with diisopropyl ether. The resulting precipitate was collected by filtration, washed with diisopropyl ether and dried to give [2,2′]bithiophenyl-5-carboxylic acid (952 mg, 75.6%).

1. stirringthe mixture was stirred at ambient temperature for 30 minutes
2. washThe separated organic layer was washed with brine
3. dry with materialdried over magnesium sulfate
4. customevaporated under reduced pressure
5. customThe residue was triturated with diisopropyl ether
6. filtrationThe resulting precipitate was collected by filtration
7. washwashed with diisopropyl ether
8. customdried