Pyridine → HCID 67255836, compound

HRID 1835510Notes

Reaction equation

HRID 1835510 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:20])[CH:5]=[C:6]([Cl:19])[C:7]=1[S:8][C:9]1[CH:18]=[CH:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=1.N1C=CC=CC=1.[Cl:27][C:28]1[N:29]=[C:30]2[N:34]([C:35]=1[S:36](Cl)(=[O:38])=[O:37])[CH:33]=[CH:32][S:31]2>C1COCC1>[Cl:19][C:6]1[CH:5]=[C:4]([NH:20][S:36]([C:35]2[N:34]3[C:30]([S:31][CH:32]=[CH:33]3)=[N:29][C:28]=2[Cl:27])(=[O:37])=[O:38])[CH:3]=[C:2]([Cl:1])[C:7]=1[S:8][C:9]1[CH:18]=[CH:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 27997176-Chloroimidazo(2,1-b)(1,3)thiazole-5-sulfonyl chlorideHCID 221488343,5-Dichloro-4-(napthalen-2-ylsulfanyl)-phenylamine

Product 1

HCID 67255836HCID 67255836, compoundYield 67.7%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared using the method of example 94, starting with 3,5-dichloro-4-(naphthalen-2-ylsulfanyl)-phenylamine (90) (150 mg, 0.47 mmol), pyridine (Aldrich, 0.19 mL, 2.34 mmol) and 6-chloro-imidazo[2,1-b]thiazole-5-sulfonyl chloride (Maybridge, 132 mg, 0.52 mmol) in THF. 172 mg (65%) of 102 was obtained as a pale yellow solid.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-b7216f5d6a6749899ef08d656546ea67
Source dataset
uspto-grants-2004_08
Patent number
US06770648B2

Reaction notes

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