HRID1835581

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2734323

3-Chlorophenylboronic acid

C6H6BClO2

结构：CCOC(=O)c1ccc2c(c1)nc(-c1ccc(Oc3cccc(Br)c3)cc1)n2C1CCCCC1

HCID9914616

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1ccc2c(c1)nc(-c1ccc(Oc3cccc(-c4cccc(Cl)c4)c3)cc1)n2C1CCCCC1

HCID10231019

未命名化合物

收率 85.6%

PROCEDURE

实验过程

Ethyl 2-[4-(3-bromophenoxy)phenyl]-1-cyclohexylbenzimidazole-5-carboxylate (65 g) obtained in Example 1 and 3-chlorophenylboronic acid (23 g) were treated in the same manner as in Example 5 to give the title compound (59 g, yield 85%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-aaf9765864a54fc4992ee6b11ecf0c70
来源数据集: uspto-grants-2004_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06770666B2
来源说明: uspto-grants-2004_08

反应 SMILES

Br[C:2]1[CH:3]=[C:4]([CH:32]=[CH:33][CH:34]=1)[O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:16]([CH:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)[C:15]3[CH:23]=[CH:24][C:25]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:26][C:14]=3[N:13]=2)=[CH:8][CH:7]=1.[Cl:35][C:36]1[CH:37]=[C:38](B(O)O)[CH:39]=[CH:40][CH:41]=1>>[Cl:35][C:36]1[CH:41]=[C:40]([C:2]2[CH:3]=[C:4]([CH:32]=[CH:33][CH:34]=2)[O:5][C:6]2[CH:11]=[CH:10][C:9]([C:12]3[N:16]([CH:17]4[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]4)[C:15]4[CH:23]=[CH:24][C:25]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:26][C:14]=4[N:13]=3)=[CH:8][CH:7]=2)[CH:39]=[CH:38][CH:37]=1