Hydrochloric Acid → HCID 23500369, compound

HRID 1835684Notes

Reaction equation

HRID 1835684 reaction equation
[C:1]1([CH:9]=[C:7]([OH:8])[CH:6]=[C:4]([OH:5])[CH:3]=1)[OH:2].[N+:10]([C:13]1[CH:28]=[CH:27][C:16]([CH2:17][CH:18]([C:24]([CH3:26])=O)[C:19](OCC)=[O:20])=[CH:15][CH:14]=1)([O-:12])=[O:11].Cl>C(O)C>[OH:2][C:1]1[C:9]2[C:24]([CH3:26])=[C:18]([CH2:17][C:16]3[CH:27]=[CH:28][C:13]([N+:10]([O-:12])=[O:11])=[CH:14][CH:15]=3)[C:19](=[O:20])[O:8][C:7]=2[CH:6]=[C:4]([OH:5])[CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 359PhloroglucinolHCID 13440195HCID 13440195, compound

Product 1

HCID 23500369HCID 23500369, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of phloroglucinol (0.48 g) and ethyl 2-(4-nitrobenzyl)aceto-acetate (1.00 g) in ethanol (150 ml) was treated with dry HCl at 0° C. for 7.5 hours and the solution was kept at that temperature overnight. Solvent was evaporated and the precipitate triturated with water. Yield 0.63 g (51%). Melting point 280-285° C.

Workup

  1. customwas kept at that temperature overnight
  2. customSolvent was evaporated
  3. customthe precipitate triturated with water

Sources & evidence

ORD record
ord-87d70f8b76cf4d56ba6a7568ae452f4e
Source dataset
uspto-grants-2004_08
Patent number
US06774103B1

Reaction notes

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