Hydrochloric Acid → HCID 23500377, compound

HRID 1835686Notes

Reaction equation

HRID 1835686 reaction equation
[C:1]1([CH:9]=[C:7]([OH:8])[CH:6]=[C:4]([OH:5])[CH:3]=1)[OH:2].[C:10]1([CH2:20][CH:21]([C:27]([CH3:29])=O)[C:22](OCC)=[O:23])[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=[CH:12][CH:11]=1.Cl>C(O)C>[OH:2][C:1]1[C:9]2[C:27]([CH3:29])=[C:21]([CH2:20][C:10]3[C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[CH:13]=[CH:12][CH:11]=3)[C:22](=[O:23])[O:8][C:7]=2[CH:6]=[C:4]([OH:5])[CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 359PhloroglucinolHCID 10265152HCID 10265152, compound

Product 1

HCID 23500377HCID 23500377, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of phloroglucinol (0.47 g) and ethyl 2-(1-naphtylmethyl)-acetoacetate (1.00 g) in ethanol (20 ml) was treated with dry HCl at 0° C. for 3 hours and the solution kept at that temperature overnight. Solvent was evaporated and the precipitate triturated with water and recrystallized from isopropanol-water (1:1). Yield 0,96 g (78%). Melting point 275-280° C.

Workup

  1. customkept at that temperature overnight
  2. customSolvent was evaporated
  3. customthe precipitate triturated with water
  4. customrecrystallized from isopropanol-water (1:1)

Sources & evidence

ORD record
ord-74bffe0486674955ab67ed5ef8566b33
Source dataset
uspto-grants-2004_08
Patent number
US06774103B1

Reaction notes

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