Acetyl chloride → HCID 23500854, compound

HRID 1835768Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.CO[C:9]1[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=1[CH:11]=O.[C:17]([Cl:20])(=O)C>>[Cl-:20].[CH3:11][C:10]1[CH:13]=[CH:14][CH:15]=[CH:16][C:9]=1[CH:17]=[N+:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

Reactant 3

HCID 6367Acetyl chloride

HCID 8083Morpholine

HCID 86582-Methoxybenzaldehyde

Product 1

HCID 23500854HCID 23500854, compound

Procedure

The reaction of 8.5 g (0.100 mol) morpholine and 7.0 g (0.050 mol) 2-methoxybenzaldehyde in accordance with general synthesis instructions 2 and subsequent reaction with 3.9 g (0.050 mol) acetyl chloride in accordance with general synthesis instructions 3 gave 7.1 g (corresponding to 58% of the yield calculated by theory) 4-(2-methyl-benzylidene)-morpholin-4-ium chloride.

Workup

customwith general synthesis instructions 3

Sources & evidence

ORD record: ord-e31dd4fc2a1e458796e236e068312818
Source dataset: uspto-grants-2004_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06774136B2

Reaction notes

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