反应详情

温度

80 °C

A mixture containing 4-(2-hydroxymethyl-benzoimidazol-1-yl)-butyronitrile, 25a, (40.0 g, 186 mmol), hydroxylamine hydrochloride (46.5 g, 0.689 mole) and potassium carbonate (51.4 g, 0.372 mole) in ethanol (400 mL) and water (200 mL) was heated at 80° C. and stirred overnight. The solvents were removed in vacuo and water was added. The white precipitate was collected by filtration, washed with water and dried in vacuo to afford N-hydroxy-4-(2-hydroxymethyl-benzoimidazol-1-yl)-butyramidine (35.8 g, 78%) as a white solid:

1. customThe solvents were removed in vacuo and water
2. additionwas added
3. filtrationThe white precipitate was collected by filtration
4. washwashed with water
5. customdried in vacuo