Potassium Carbonate → HCID 178511040, compound

HRID 1835837Notes

Reaction equation

HRID 1835837 reaction equation
[OH:1][CH2:2][C:3]1[N:7]([CH2:8][CH2:9][CH2:10][C:11]#[N:12])[C:6]2[CH:13]=[CH:14][CH:15]=[CH:16][C:5]=2[N:4]=1.Cl.[NH2:18][OH:19].C(=O)([O-])[O-].[K+].[K+]>C(O)C.O>[OH:19][NH:18][C:11](=[NH:12])[CH2:10][CH2:9][CH2:8][N:7]1[C:6]2[CH:13]=[CH:14][CH:15]=[CH:16][C:5]=2[N:4]=[C:3]1[CH2:2][OH:1]

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 225957974-(2-Hydroxymethyl-benzoimidazol-1-yl)-butyronitrile

Product 1

HCID 178511040HCID 178511040, compoundYield 78%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

A mixture containing 4-(2-hydroxymethyl-benzoimidazol-1-yl)-butyronitrile, 25a, (40.0 g, 186 mmol), hydroxylamine hydrochloride (46.5 g, 0.689 mole) and potassium carbonate (51.4 g, 0.372 mole) in ethanol (400 mL) and water (200 mL) was heated at 80° C. and stirred overnight. The solvents were removed in vacuo and water was added. The white precipitate was collected by filtration, washed with water and dried in vacuo to afford N-hydroxy-4-(2-hydroxymethyl-benzoimidazol-1-yl)-butyramidine (35.8 g, 78%) as a white solid:

Workup

  1. customThe solvents were removed in vacuo and water
  2. additionwas added
  3. filtrationThe white precipitate was collected by filtration
  4. washwashed with water
  5. customdried in vacuo

Sources & evidence

ORD record
ord-a5ba4fc5afdb44428d5461240ec3c0f3
Source dataset
uspto-grants-2004_08
Patent number
US06774134B2

Reaction notes

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