Methane → HCID 9881552, compound

HRID 1835848Notes

Reaction equation

HRID 1835848 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][C:3]2([C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[NH:8][C:7]2=[O:15])[CH2:2]1.[CH:16]1([CH:19]=O)[CH2:18][CH2:17]1.C>>[CH:16]1([CH2:19][N:1]2[CH2:6][CH2:5][CH2:4][C:3]3([C:14]4[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=4)[NH:8][C:7]3=[O:15])[CH2:2]2)[CH2:18][CH2:17]1

Participants

4

Reactant 3

HCID 297MethaneHCID 123114CyclopropanecarboxaldehydeHCID 9859066HCID 9859066, compound

Product 1

HCID 9881552HCID 9881552, compoundYield 90%

Procedure

The compound was prepared according to PROCEDURE 1, Method A by reaction of spiro[indoline-3,3′-piperidin]-2-one with 3 equiv. of cyclopropanecarboxaldehyde. Yield: 90%. 13C NMR (CDCl3): δ 3.8, 4.0, 8.3, 21.4, 31.8, 48.6, 53.3, 58.4, 63.6, 109.7, 121.7, 126.1, 127.4, 134.7, 140.0, 182.2; MS (CI, CH4): m/z (rel. int.) 257 (M+1, 100).

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-55731c172748454598d4f54a65c54750
Source dataset
uspto-grants-2004_08
Patent number
US06774132B1

Reaction notes

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