Methane → HCID 23500704, compound

HRID 1835850Notes

Reaction equation

HRID 1835850 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][C:3]2([C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[NH:8][C:7]2=[O:15])[CH2:2]1.[CH3:16][C:17](=O)[CH2:18][CH3:19].C>>[CH:17]([N:1]1[CH2:6][CH2:5][CH2:4][C:3]2([C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[NH:8][C:7]2=[O:15])[CH2:2]1)([CH2:18][CH3:19])[CH3:16]

Participants

4

Reactant 3

HCID 297MethaneHCID 6569Methyl Ethyl KetoneHCID 9859066HCID 9859066, compound

Product 1

HCID 23500704HCID 23500704, compoundYield 46%

Procedure

The compound was prepared according to PROCEDURE 1, Method A by reaction with spiro[indoline-3,3′-piperidin]-2-one and 2-butanone (3 equivalents). Yield: 46%. 13C NMR (CDCl3): δ 11.5, 11.6, 13.3, 13.3, 21.7, 21.9, 26.4, 26.5, 32.1, 32.1, 46.1, 48.6, 49.0, 50.9, 52.4, 56.6, 61.2, 62.5, 109.6, 121.5, 121.6, 126.4, 126.5, 127.2, 134.7, 134.9, 140.1, 140.1, 182.4, 182.5; MS (CI, CH4): m/z (rel. int.) 259 (M+1, 100).

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-8bb57af6ad5344dda5350f1569430535
Source dataset
uspto-grants-2004_08
Patent number
US06774132B1

Reaction notes

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