3-Aminopyridine → HCID 23500659, compound

HRID 1835856Notes

Reaction equation

HRID 1835856 reaction equation
Br[C:2]1[CH:16]=[CH:15][CH:14]=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1)=[O:5].Br[C:18]1[CH:26]=CC=C[C:19]=1C([Cl:22])=O.NC1C=NC=CC=1>N1C=CC=CC=1>[ClH:22].[CH2:19]([N:9]1[CH2:10][CH2:11][CH2:12][C:7]2([C:13]3[C:3](=[CH:2][CH:16]=[CH:15][CH:14]=3)[C:4](=[O:5])[NH:6]2)[CH2:8]1)[CH2:18][CH3:26]

Participants

5

Reactant 3

HCID 100093-AminopyridineHCID 235422-Bromobenzoyl chlorideHCID 603207HCID 603207, compound

Product 1

HCID 23500659HCID 23500659, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent2×

Procedure

2-Bromo-N-(3-pyridyl)benzamide. To a solution of 2-bromobenzoylchloride (11.6 g) in dry pyridine (50 ml) at rt., 3-aminopyridine (5.0 g) dissolved in dry pyridine was added. After stirring for 12 hours and extractive work-up 7.77 g of the title product was obtained as white crystals. MS(ESP+) m/z: 279 (M+H+, 98), 277 (M+H+, 100).

Workup

  1. customat rt
  2. additionwas added

Sources & evidence

ORD record
ord-0b63b456d36b48e0a982b1cbc70c238e
Source dataset
uspto-grants-2004_08
Patent number
US06774132B1

Reaction notes

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