Hydrochloric Acid → HCID 23500684, compound

HRID 1835860Notes

Reaction equation

HRID 1835860 reaction equation
[ClH:1].[NH:2]1[CH2:8][CH:7]=[CH:6][CH2:5][C@:4]2([C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][C:9]2=[O:17])[CH2:3]1.Cl>CO.CCOCC>[ClH:1].[NH:2]1[CH2:8][CH:7]=[CH:6][CH2:5][C:4]2([C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][C:9]2=[O:17])[CH2:3]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 23516960HCID 23516960, compound

Product 1

HCID 23500684HCID 23500684, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

(S)-Spiro[indoline-3,3′-(1,3,4,7-tetrahydro-2H-azepin)]-2-one Hydrochloride The material from the second peak from STEP C (47 mg) was dissolved in methanol (5 ml) and treated with HCl in ether (1.5 ml) at room temperature overnight. The title compound was obtained upon removal of solvents. MS (TSP+) m/z [M+H]+: 215. 13C NMR: (CD3OD): 181.0, 142.1, 132.7, 132.2, 130.4, 125.7, 124.8, 123.8, 111.6, 53.8, 47.6, 47.5, 35.4 ppm.

Sources & evidence

ORD record
ord-cd6a9af09327414bb4c24d0ce14c4b6e
Source dataset
uspto-grants-2004_08
Patent number
US06774132B1

Reaction notes

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