Dimethylamine → 3-[3-(4-Methylpiperazin-1-yl)-propyl]-4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde

HRID 1836124Notes

Reaction equation

[CH3:1][N:2]([CH3:17])[CH2:3][CH2:4][CH2:5][C:6]1[C:14]2[CH2:13][CH2:12][CH2:11][CH2:10][C:9]=2[NH:8][C:7]=1[CH:15]=[O:16].[CH3:18][N:19]1[CH2:24]CNC[CH2:20]1.CNC>>[CH3:18][N:19]1[CH2:24][CH2:1][N:2]([CH2:3][CH2:4][CH2:5][C:6]2[C:14]3[CH2:13][CH2:12][CH2:11][CH2:10][C:9]=3[NH:8][C:7]=2[CH:15]=[O:16])[CH2:17][CH2:20]1

Participants

Reactant 3

HCID 674Dimethylamine

HCID 531671-Methylpiperazine

HCID 112300633-(3-(Dimethylamino)propyl)-4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde

Product 1

HCID 225711323-[3-(4-Methylpiperazin-1-yl)-propyl]-4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde

Procedure

3-[3-(4-Methylpiperazin-1-yl)-propyl]-4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde was prepared following the procedure described for 3-(3-dimethylamino-propyl)-4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde as described for Example 1 above but substituting 1-methylpiperazine in step 2 above for dimethylamine.

Sources & evidence

ORD record: ord-96b86d98d2fb4b09b14db05bffafc9e5
Source dataset: uspto-grants-2004_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06777417B2

Reaction notes

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