4-Fluoroaniline → HCID 2653166, compound

HRID 1836435Notes

Reaction equation

HRID 1836435 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][N:3]=1.[F:11][C:12]1[CH:18]=[CH:17][C:15]([NH2:16])=[CH:14][CH:13]=1.C(N(CC)C(C)C)(C)C>ClCCl>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:16][C:15]2[CH:17]=[CH:18][C:12]([F:11])=[CH:13][CH:14]=2)=[O:7])=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 97314-FluoroanilineHCID 81531DiisopropylethylamineHCID 27821656-Chloronicotinoyl Chloride

Product 1

HCID 2653166HCID 2653166, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a suspension of 6-chloronicotinoyl chloride (10.5 g, 59.7 mmole) in dry dichloromethane (100 mL) was added 4-fluoroaniline (5.6 mL, 59.7 mmole), followed by the dropwise addition of N,N-diisopropylethylamine (21 mL, 19 mmol).

Sources & evidence

ORD record
ord-9ef1827f3fcf4acfa22c08a05c25714b
Source dataset
uspto-grants-2004_08
Patent number
US06777432B1

Reaction notes

Loading…