4-(Trifluoromethyl)benzaldehyde → 4-Trifluoromethyl-benzaldehyde o-methyloxime

HRID 1836522Notes

Reaction equation

HRID 1836522 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][C:6]([CH:7]=O)=[CH:5][CH:4]=1.Cl.[O:14]([NH2:16])[CH3:15]>>[CH3:15][O:14][N:16]=[CH:7][C:6]1[CH:9]=[CH:10][C:3]([C:2]([F:12])([F:11])[F:1])=[CH:4][CH:5]=1

Participants

3

Reactant 2

HCID 679964-(Trifluoromethyl)benzaldehydeHCID 521874O-Methylhydroxylamine hydrochloride

Product 1

HCID 740573304-Trifluoromethyl-benzaldehyde o-methyloximeYield 100%

Procedure

Reaction of 4-trifluoromethylbenzaldehyde with methoxylamine hydrochloride as described in the preparation of compound 3-A gave the title oxime ether as a clear oil (100% yield). 1HNMR indicated a 9:1 mixture of E- and Z-isomers. 1HNMR 400 MHz (CDCl3) δ (ppm): (E-isomer) 4.00 (3H, s, OCH3), 7.62 (2H, m, aromatics), 7.69 (2H, m, aromatics), 8.08 (1H, s, CH).

Sources & evidence

ORD record
ord-cab013eb2f3f437f98ffaf06c1a35bb6
Source dataset
uspto-grants-2004_08
Patent number
US06777440B2

Reaction notes

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