O-Methylhydroxylamine hydrochloride → HCID 74058497, compound

HRID 1836534Notes

Reaction equation

HRID 1836534 reaction equation
[C:1]([O:5][C:6](=[O:15])[C:7]1[CH:12]=[CH:11][C:10]([CH:13]=O)=[CH:9][CH:8]=1)([CH3:4])([CH3:3])[CH3:2].Cl.[O:17]([NH2:19])[CH3:18]>>[C:1]([O:5][C:6](=[O:15])[C:7]1[CH:12]=[CH:11][C:10]([CH:13]=[N:19][O:17][CH3:18])=[CH:9][CH:8]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 2751588Tert-butyl 4-formylbenzoate

Product 1

HCID 74058497HCID 74058497, compound

Procedure

Reaction of 4-formyl-benzoic acid tert-butyl ester with methoxylamine hydrochloride as described in the preparation of compound 3-A gave the title oxime ether as a clear oil after chromatography on silica gel ( elution hexane-ethyl acetate, 96:4) (79% yield). 1HNMR 400 MHz (CDCl3) δ (ppm): 1.60 (9H, s, t-Bu), 4.00 (3H, s, OCH3), 7.62 (2H, d, J=8.0 Hz, aromatics), 7.97 (2H, d, J=8.0 Hz, aromatics), 8.08 (1H, s, CH).

Sources & evidence

ORD record
ord-1063aaf635ef4dcd9ded6cdd93900365
Source dataset
uspto-grants-2004_08
Patent number
US06777440B2

Reaction notes

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