反应详情

温度

90 °C

An autoclave was charged under an argon flow with 1.066 g of acetic acid 1-(1-benzenesulfonyl-1H-indol-2-yl)-allyl ester (3.0 mmol, oil, crude quality), 0.57 ml of acetic anhydride (6.0 mmol), 0.92 ml of triethylamine (6.6 mmol) and 2.5 ml of a catalyst solution prepared from 6.73 mg of palladium acetate (0.030 mmol) and 78.7 mg of triphenylphosphine (0.30 mmol) in 25 ml of toluene. Then the autoclave was sealed, pressurized three times with 20 bar of carbon monoxide and vented, and finally pressurized with 50 bar of carbon monoxide. The reaction mixture was stirred magnetically and heated at 90° C. for 20 h. After cooling and venting the autocave, the dark reaction mixture was poured onto ice water and the biphasic solution stirred vigorously for 1 h. The aqueous phase was extracted with 20 ml of toluene, whereas the toluene phase was extracted in a separatory funnel with 10 ml of water and 10 ml of brine. The combined toluene phases were dried on sodium sulfate and finally rotary evaporated (47° C., 10 mbar). The resulting brown residue was purified by chromatography on silica gel (eluent: cyclohexane/tbutyl methyl ether 2:1 vol/vol) to afford 960 mg (88%) of acetic acid 9-benzenesulfonyl-9H-carbazol-4-yl ester as a light brown oil.

1. customThen the autoclave was sealed
2. temperatureAfter cooling
3. customthe dark reaction mixture
4. additionwas poured onto ice water
5. stirringthe biphasic solution stirred vigorously for 1 h
6. extractionThe aqueous phase was extracted with 20 ml of toluene, whereas the toluene phase
7. extractionwas extracted in a separatory funnel with 10 ml of water and 10 ml of brine
8. dry with materialThe combined toluene phases were dried on sodium sulfate
9. customfinally rotary evaporated (47° C., 10 mbar)
10. customThe resulting brown residue was purified by chromatography on silica gel (eluent: cyclohexane/tbutyl methyl ether 2:1 vol/vol)