Water → HCID 9864311, compound

HRID 1836978Notes

Reaction equation

HRID 1836978 reaction equation
CS([C:5]1[N:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:13][CH:12]=2)[CH:8]=[C:7]([C:21]([F:24])([F:23])[F:22])[N:6]=1)(=O)=O.[CH2:25]([NH2:29])[CH:26]([CH3:28])[CH3:27].O>CN1C(=O)CCC1>[CH2:25]([NH:29][C:5]1[N:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:13][CH:12]=2)[CH:8]=[C:7]([C:21]([F:24])([F:23])[F:22])[N:6]=1)[CH:26]([CH3:28])[CH3:27]

Participants

5

Reactant 3

HCID 962WaterHCID 6558IsobutylamineHCID 111764432-(Methylsulfonyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidine

Product 1

HCID 9864311HCID 9864311, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

A mixture of 2-(methylsulfonyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidine (1 g, 2.629 mmol) and isobutylamine(0.52 ml) in NMP (10 ml) was stirred at ambient temperature for 18 h. Water (100 ml) was then added and the resulting precipitate was collected by filtration and dried (0.85 g). Trituration of this material with ether/cyclohexane gave the title compound as a colourless solid (0.62 g).

Workup

  1. filtrationthe resulting precipitate was collected by filtration
  2. customdried (0.85 g)

Sources & evidence

ORD record
ord-eabc70ab034f4baa8b5debd6d6ab21c9
Source dataset
uspto-grants-2004_08
Patent number
US06780869B1

Reaction notes

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