4-Methoxybenzylamine → HCID 10137965, compound

HRID 1836990Notes

Reaction equation

HRID 1836990 reaction equation
CS([C:5]1[N:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:13][CH:12]=2)[CH:8]=[C:7]([C:21]([F:24])([F:23])[F:22])[N:6]=1)(=O)=O.[CH3:25][O:26][C:27]1[CH:34]=[CH:33][C:30]([CH2:31][NH2:32])=[CH:29][CH:28]=1>CN1CCCC1=O.O>[CH3:25][O:26][C:27]1[CH:34]=[CH:33][C:30]([CH2:31][NH:32][C:5]2[N:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:13][CH:12]=3)[CH:8]=[C:7]([C:21]([F:24])([F:23])[F:22])[N:6]=2)=[CH:29][CH:28]=1

Participants

5

Reactant 2

HCID 754524-MethoxybenzylamineHCID 111764432-(Methylsulfonyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidine

Product 1

HCID 10137965HCID 10137965, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

A stirred solution of 2-(methylsulfonyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidine (1 g, 2.629 mmol) in N-methylpyrrolidone (10 ml) was treated with 4-methoxybenzylamine (0.69 ml). The mixture was stirred at room temperature for 18 h and was then diluted with water (50 ml). This gave a cream solid, which was triturated with diethyl ether giving the title compound as a colourless solid (0.98 g).

Workup

  1. customThis gave a cream solid, which
  2. customwas triturated with diethyl ether giving the title compound as a colourless solid (0.98 g)

Sources & evidence

ORD record
ord-c790406c7d174a88b65095e3157e99e9
Source dataset
uspto-grants-2004_08
Patent number
US06780870B2

Reaction notes

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