Piperazine → HCID 15512465, compound

HRID 1837130Notes

Reaction equation

HRID 1837130 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][CH2:11]Br)=[CH:2]1.N1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1.C(=O)([O-])[O-].[K+].[K+].[C:25](#[N:27])C>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][CH2:11][N:16]2[CH2:15][CH2:14][CH:25]([NH2:27])[CH2:18][CH2:17]2)=[CH:2]1

Participants

5

Reactant 4

HCID 4837PiperazineHCID 6342AcetonitrileHCID 11430Potassium CarbonateHCID 150754803-(2-bromoethyl)Benzofuran

Product 1

HCID 15512465HCID 15512465, compound

Procedure

84 mmol of 2-(benzofuran-3-yl)-1-bromoethane, 67 mmol of piperazine and 56 mmol of potassium carbonate are added to 200 ml of acetonitrile. After refluxing for 4 hours, the reaction mixture is cooled and then concentrated. The residue is taken up in dichloromethane, is washed with water, dried, filtered and then concentrated under reduced pressure. Chromatography over silica gel (dichloromethane/ethanol: 90/10) allows the expected product to be isolated.

Workup

  1. temperatureAfter refluxing for 4 hours
  2. temperaturethe reaction mixture is cooled
  3. concentrationconcentrated
  4. washis washed with water
  5. customdried
  6. filtrationfiltered
  7. concentrationconcentrated under reduced pressure
  8. customto be isolated

Sources & evidence

ORD record
ord-b8a7f95a1e2047d8a34ace53c80ef130
Source dataset
uspto-grants-2004_08
Patent number
US06780868B2

Reaction notes

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