反应详情

3.55 g of methylamine is condensed in a solution of 2.6 ml of 1,1,1,2,2,3,3 heptafluor-5-iodo-pentane in 20 ml of anhydrous tetrahydrofuran at −40° C., and it is stirred overnight at room temperature in a pressurized reactor. After the pressurized reactor was opened at −30° C., it is allowed to come to room temperature to allow excess methylamine to evaporate off. Then, the reaction solution is mixed with diethyl ether, washed with saturated common salt solution, dried on magnesium sulfate and concentrated by evaporation in a vacuum. 1.26 g of (3,4,4,5,5,5-hexafluoro-pent-2-enyl)-methyl-amine is obtained as a crude product.

1. customwas opened at −30° C.
2. customto come to room temperature
3. customto evaporate off
4. additionThen, the reaction solution is mixed with diethyl ether
5. washwashed with saturated common salt solution
6. customdried on magnesium sulfate
7. concentrationconcentrated by evaporation in a vacuum