Potassium Carbonate → HCID 21960150, compound

HRID 1837312Notes

Reaction equation

HRID 1837312 reaction equation
[CH2:1]([C:3]1[NH:4][C:5](=[O:13])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[N:8]=1)[CH3:2].Br[CH2:15][CH2:16][O:17][C:18]1[CH:25]=[CH:24][C:21]([CH:22]=[O:23])=[CH:20][CH:19]=1.C([O-])([O-])=O.[K+].[K+]>>[CH2:1]([C:3]1[N:4]([CH2:15][CH2:16][O:17][C:18]2[CH:25]=[CH:24][C:21]([CH:22]=[O:23])=[CH:20][CH:19]=2)[C:5](=[O:13])[CH:6]=[C:7]([C:9]([F:11])([F:12])[F:10])[N:8]=1)[CH3:2]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 2627064-(2-Bromoethoxy)BenzaldehydeHCID 135678130HCID 135678130, compound

Product 1

HCID 21960150HCID 21960150, compoundYield 40%

Procedure

The title compound (138 mg, 40%) was prepared from 2-ethyl-4-trifluoromethyl-1,6-dihydro-6-pyrimidone (200 mg, 1.04 mmol) and 4-[2-bromoethoxy]benzaldehyde (238.5 mg, 1.04 mmol) in presence of K2CO3 (287.5 mg, 2.08 mmol) as base by a similar procedure to that described in preparation 1.

Workup

  1. customthat described in preparation 1

Sources & evidence

ORD record
ord-0873428c050940678b6fa117134bd5b2
Source dataset
uspto-grants-2004_08
Patent number
US06780992B2

Reaction notes

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