Phosphorus oxychloride → HCID 23498112, compound

HRID 1837342Notes

Reaction equation

HRID 1837342 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][C:18]=1[O:19][CH2:20][CH2:21][O:22][CH3:23])[N:15]=[CH:14][C:13]([C:24]#[N:25])=[C:12]2O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:29])=O>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][C:18]=1[O:19][CH2:20][CH2:21][O:22][CH3:23])[N:15]=[CH:14][C:13]([C:24]#[N:25])=[C:12]2[Cl:29])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178496075HCID 178496075, compound

Product 1

HCID 23498112HCID 23498112, compoundYield 67%

Procedure

Following the procedure used to prepare Reference Example 12, reaction of 6-benzyloxy-4-hydroxy-7-(2-methoxyethoxy)-3-quinolinecarbonitrile with phosphorous oxychloride provides 6-benzyloxy-4-chloro-7-(2-methoxyethoxy)-3-quinolinecarbonitrile in 67% yield, mp 142-145° C.

Workup

  1. customto prepare

Sources & evidence

ORD record
ord-8066f5cfe7e34389aa12f6473f66072a
Source dataset
uspto-grants-2004_08
Patent number
US06780996B2

Reaction notes

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