3-Nitrophenylethyl alcohol → 2-(3-nitrophenyl)acetaldehyde

HRID 1837510Notes

Reaction equation

HRID 1837510 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][OH:12])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].OI1(=O)C2C=CC=CC=2C(=O)O1>O1CCCC1>[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][CH:11]=[O:12])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 1040583-Nitrophenylethyl alcoholHCID 3394961-Hydroxy-1,2-benziodoxol-3(1H)-one 1-oxide

Product 1

HCID 115284082-(3-nitrophenyl)acetaldehyde

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 10 g of 2-(3-nitrophenyl)ethanol, 25.1 g of 1-hydroxy-1,2-benziodoxol-3(1H)-one 1-oxide and 300 ml of tetrahydrofuran is heated at reflux for 6 hours. After filtration and concentration of the solvent, the product is used as it is in the following Step.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 6 hours
  3. filtrationAfter filtration and concentration of the solvent

Sources & evidence

ORD record
ord-d3e402bd917e4f69915b77f47a8198ff
Source dataset
uspto-grants-2004_08
Patent number
US06784183B2

Reaction notes

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