Trifluoroacetic acid → HCID 11323531, compound

HRID 1837605Notes

Reaction equation

HRID 1837605 reaction equation
FC(F)(F)C(O)=O.[CH:8]([C:11]1[S:15][C:14]([NH:16][C:17](=[O:32])[CH2:18][C:19]2[N:20]=[C:21]([NH:24]C(=O)OC(C)(C)C)[S:22][CH:23]=2)=[N:13][CH:12]=1)([CH3:10])[CH3:9].C1(OC)C=CC=CC=1>C(Cl)Cl>[NH2:24][C:21]1[S:22][CH:23]=[C:19]([CH2:18][C:17]([NH:16][C:14]2[S:15][C:11]([CH:8]([CH3:10])[CH3:9])=[CH:12][N:13]=2)=[O:32])[N:20]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 9929892HCID 9929892, compound

Product 1

HCID 11323531HCID 11323531, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (168 ml) was added to a solution of tert-butyl 4-{2-[(5-isopropyl-1,3-thiazol-2-yl)amino]-2-oxoethyl}-1,3-thiazol-2-ylcarbamate (22 g, 57.51 mmol) in CH2Cl2 (750 ml) and anisole (9.33 ml, 86.27 mmol) under ice-cooling.

Workup

  1. temperaturecooling

Sources & evidence

ORD record
ord-2c54088e033644dd97e532bf687cca35
Source dataset
uspto-grants-2004_08
Patent number
US06784198B1

Reaction notes

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