Hydrochloric Acid → HCID 22678561, compound

HRID 1837688Notes

Reaction equation

HRID 1837688 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][C:16]2[S:17][CH:18]=[CH:19][C:20]=2[S:21]([CH3:24])(=[O:23])=[O:22])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:25]>C(OCC)(=O)C>[ClH:25].[CH3:24][S:21]([C:20]1[CH:19]=[CH:18][S:17][C:16]=1[CH2:15][CH2:14][CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)(=[O:22])=[O:23]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 226783201-Tert-butoxycarbonyl-4-[2-(3-methylsulfonyl-2-thienyl)ethyl]piperidine

Product 1

HCID 22678561HCID 22678561, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

11.1 g of 1-tert-butoxycarbonyl-4-[2-(3-methylsulfonyl-2-thienyl)ethyl]piperidine was dissolved in 100 ml of ethyl acetate, 100 ml of an ethyl acetate solution of 4N hydrochloric acid was added thereto, and the mixture was further stirred at room temperature for 2 hours. The resulting crystals were collected by filtration, washed with ethyl acetate, and air-dried, to give 7.92 g of the title compound as colorless crystals.

Workup

  1. filtrationThe resulting crystals were collected by filtration
  2. washwashed with ethyl acetate
  3. customair-dried

Sources & evidence

ORD record
ord-e6d41132ce9540478b98fcd511322d1d
Source dataset
uspto-grants-2004_08
Patent number
US06784192B2

Reaction notes

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