Potassium Carbonate → HCID 135617197, compound

HRID 1838128Notes

Reaction equation

HRID 1838128 reaction equation
Br[C:2]1[N:7]=[C:6]([CH3:8])[NH:5][C:4](=[O:9])[C:3]=1[N+:10]([O-:12])=[O:11].[OH:13][C:14]1([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[OH:13][C:14]1([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:19][CH2:18][N:17]([C:2]2[N:7]=[C:6]([CH3:8])[NH:5][C:4](=[O:9])[C:3]=2[N+:10]([O-:12])=[O:11])[CH2:16][CH2:15]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 963874-Phenylpiperidin-4-olHCID 1356171936-bromo-2-methyl-5-nitro-3H-pyrimidin-4-one

Product 1

HCID 135617197HCID 135617197, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In analogy to the procedure described in example 1, the 6-bromo-2-methyl-5-nitro-3H-pyrimidin-4-one (as prepared in Eur. Pat. Appl. EP 1 074 549 A2) was treated with the 4-hydroxy-4-phenylpiperidine in N,N-dimethylformamide in the presence of potassium carbonate at room temperature to yield the 6-(4-hydroxy-4-phenyl-piperidin-1-yl)-2-methyl-5-nitro-3H-pyrimidin-4-one as yellow solid; m.p.>250° C. (decomposition); MS: [M+H]+=331.

Sources & evidence

ORD record
ord-972e60df0c174cd9886acd199a8a1663
Source dataset
uspto-grants-2004_01
Patent number
US06673795B2

Reaction notes

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