Potassium Carbonate → HCID 18753278, compound

HRID 1838139Notes

Reaction equation

HRID 1838139 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([C:14]3[N:19]=[C:18]([CH3:20])[NH:17][C:16](=[O:21])[C:15]=3[N+:22]([O-:24])=[O:23])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Cl[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][OH:32].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:9][CH2:10][N:11]([C:14]3[N:19]=[C:18]([CH3:20])[N:17]=[C:16]([O:21][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][OH:32])[C:15]=3[N+:22]([O-:24])=[O:23])[CH2:12][CH2:13]2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 748286-Chloro-1-hexanolHCID 135617196HCID 135617196, compound

Product 1

HCID 18753278HCID 18753278, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In analogy to the procedure described in example 8, the 6-[4-(4-fluoro-phenyl)-piperazin-1-yl]-2-methyl-5-nitro-3H-pyrimidin-4-one (example 1) was treated with 6-chloro-1-hexanol and potassium carbonate in N,N-dimethylformamide at 120° C. to yield the 6-{6-[4-(4-fluoro-phenyl)-piperazin-1-yl]-2-methyl-5-nitro-pyrimidin-4-yloxy}-hexan-1-ol as a yellow amorphous solid; MS: [M+H]+=434.

Sources & evidence

ORD record
ord-496036f9ae244fda86ca4139ef51e9cf
Source dataset
uspto-grants-2004_01
Patent number
US06673795B2

Reaction notes

Loading…