反应详情

In analogy to the procedure described in example 8, the 6-[4-(4-fluoro-phenyl)-piperidin-1-yl]-2-methyl-5-nitro-3H-pyrimidin-4-one (example 7) was treated with bromo-acetonitrile and potassium carbonate in N,N-dimethylformamide at room temperature to yield the {4-[4-(4-fluoro-phenyl)-piperidin-1-yl]-2-methyl-5-nitro-6-oxo-6H-pyrimidin-1-yl}-acetonitrile as a yellow solid; m.p. 213-215° C. (decomposition); MS: [M+H]+=372.