1-Phenylpiperazine → HCID 10156326, compound

HRID 1838163Notes

Reaction equation

HRID 1838163 reaction equation
Cl[C:2]1[C:7]([C:8]#[N:9])=[C:6](C2CC2)[N:5](N)[CH:4](C2CC2)[N:3]=1.[C:17]1([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.C([N:31]([CH:35]([CH3:37])[CH3:36])C(C)C)C>O1CCOCC1>[CH:35]1([NH:31][C:4]2[N:3]=[C:2]([NH:31][CH:35]3[CH2:36][CH2:37]3)[C:7]([C:8]#[N:9])=[C:6]([N:26]3[CH2:27][CH2:28][N:23]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[CH2:24][CH2:25]3)[N:5]=2)[CH2:37][CH2:36]1

Participants

5

Reactant 3

HCID 70961-PhenylpiperazineHCID 81531DiisopropylethylamineHCID 69036813HCID 69036813, compound

Product 1

HCID 10156326HCID 10156326, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In analogy to the procedure described in example 20b, 4-chloro-2,6-bis-cyclopropyl-amino-pyrimidine-5-carbonitrile was treated with 1-phenyl-piperazine and N-ethyl-diisopropylamine in dioxane at 90° C. to yield 2,4-bis-cyclopropylamino-6-(4-phenyl-piperazin-1-yl)-pyrimidine-5-carbonitrile as an amorphous, light yellow solid; MS: [M+H]+376.

Sources & evidence

ORD record
ord-bf31fc52b5b94c659bcd270a64d164dd
Source dataset
uspto-grants-2004_01
Patent number
US06673795B2

Reaction notes

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