3-Pyridinemethanamine → HCID 18753280, compound

HRID 1838173Notes

Reaction equation

HRID 1838173 reaction equation
Cl[C:2]1[C:7]([C:8]#[N:9])=[C:6]([Cl:10])[N:5]=[C:4]([NH:11][CH2:12][CH2:13][OH:14])[N:3]=1.[N:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][NH2:22])[CH:16]=1.C(N(C(C)C)C(C)C)C>O1CCOCC1>[Cl:10][C:6]1[C:7]([C:8]#[N:9])=[C:2]([NH:22][CH2:21][C:17]2[CH:16]=[N:15][CH:20]=[CH:19][CH:18]=2)[N:3]=[C:4]([NH:11][CH2:12][CH2:13][OH:14])[N:5]=1

Participants

5

Reactant 3

HCID 310183-PyridinemethanamineHCID 81531DiisopropylethylamineHCID 18753232HCID 18753232, compound

Product 1

HCID 18753280HCID 18753280, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In analogy to the procedure described in example 38b, 4,6-dichloro-2-(2-hydroxy-ethyl-amino)-pyrimidine-5-carbonitrile was treated with 3-picolylamine in dioxane in the presence of N-ethyl-diisopropylamine at room temperature to yield 4-chloro-2-(2-hydroxy-ethylamino)-6-[(pyridin-3-ylmethyl)-amino]-pyrimidine-5-carbonitrile as a colorless foam.

Sources & evidence

ORD record
ord-553c316fe393460e9481b54c0948b3d1
Source dataset
uspto-grants-2004_01
Patent number
US06673795B2

Reaction notes

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