Hydrochloric Acid → HCID 15521776, compound

HRID 1838222Notes

Reaction equation

HRID 1838222 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([NH:18][CH:19]([CH3:21])[CH3:20])=[CH:14][C:13]=1[O:22][CH3:23])[C:6](=[O:24])[C:5]2([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[Cl:32])[CH3:25].[CH2:33]=O.[BH4-].[Na+].Cl>C(OCC)C>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([N:18]([CH:19]([CH3:21])[CH3:20])[CH3:33])=[CH:14][C:13]=1[O:22][CH3:23])[C:6](=[O:24])[C:5]2([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[Cl:32])[CH3:25]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 4311764Sodium borohydrideHCID 10116033HCID 10116033, compound

Product 1

HCID 15521776HCID 15521776, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The compound of Example 56 is treated with aqueous formaldehyde and sodium borohydride. The compound obtained is salified with a solution of hydrochloric acid in diethyl ether. The hydrochloride is then isolated after filtration and drying at 45° C. under reduced pressure; M.p.=156° C. (HCl.1.5H2O).

Workup

  1. customThe compound obtained

Sources & evidence

ORD record
ord-db2dd9dcb6fd408389367c3a2affacad
Source dataset
uspto-grants-2004_01
Patent number
US06673790B1

Reaction notes

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