Uracil → Benzyl chloromethyl ether

HRID 1838435Notes

Reaction equation

HRID 1838435 reaction equation
N1[C:6]2[CH:7]=[CH:8]S[C:5]=2[C:4](=O)NC1=O.N1C=CC(=O)NC1=O.C[Si](C)(C)[CH2:22][CH2:23][O:24][CH2:25][Cl:26]>>[CH2:23]([O:24][CH2:25][Cl:26])[C:22]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 1174UracilHCID 27242712-Chloromethyl 2-(trimethylsilyl)ethyl etherHCID 7059273Thieno(3,2-d)pyrimidine-2,4(1H,3H)-dione

Product 1

HCID 137983Benzyl chloromethyl ether

Procedure

In a similar manner to the procedures described in Reference Example 3, reactions were carried out using thieno[3,2-d]pyrimidine-2,4-dione, instead of pyrimidine-2,4-dione, and using 2-(trimethylsilyl)ethoxymethyl chloride, instead of benzyloxymethyl chloride, to give the title compound (yield 87%) as a pale yellow powder.

Sources & evidence

ORD record
ord-c7311b8f29934c51857a3b78011c9de9
Source dataset
uspto-grants-2004_01
Patent number
US06673804B1

Reaction notes

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