Uracil → Benzyl chloromethyl ether

HRID 1838439Notes

Reaction equation

HRID 1838439 reaction equation
F[C:2](F)(F)[C:3]1[C:4](=[O:10])NC(=O)N[CH:8]=1.N1[CH:18]=[CH:17][C:16](=O)NC1=O.C[Si](C)(C)CCO[CH2:26][Cl:27]>>[CH2:4]([O:10][CH2:26][Cl:27])[C:3]1[CH:2]=[CH:18][CH:17]=[CH:16][CH:8]=1

Participants

4

Reactant 3

HCID 1174UracilHCID 5899TrifluoromethyluracilHCID 27242712-Chloromethyl 2-(trimethylsilyl)ethyl ether

Product 1

HCID 137983Benzyl chloromethyl ether

Procedure

In a similar manner to the procedures described in Reference Example 3, reactions were carried out using 5-trifluoromethylpyrimidine-2,4-dione, instead of pyrimidine-2,4-dione, and using 2-(trimethylsilyl)ethoxymethyl chloride, instead of benzyloxymethyl chloride, to give the title compound (yield 76%) as a white powder.

Sources & evidence

ORD record
ord-2ff02496eb1e41ebaf56a098b7c7495a
Source dataset
uspto-grants-2004_01
Patent number
US06673804B1

Reaction notes

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