Hydrochloric Acid → HCID 178429694, compound

HRID 1838680Notes

Reaction equation

HRID 1838680 reaction equation
[CH3:1][S:2]([C:5]1[C:16]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:15][C:8]([C:9]([NH:11][C:12]([NH2:14])=[NH:13])=[O:10])=[C:7]([CH3:21])[CH:6]=1)(=[O:4])=[O:3].[ClH:22]>C(O)C>[ClH:22].[CH3:1][S:2]([C:5]1[C:16]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:15][C:8]([C:9]([NH:11][C:12]([NH2:14])=[NH:13])=[O:10])=[C:7]([CH3:21])[CH:6]=1)(=[O:4])=[O:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178429693HCID 178429693, compound

Product 1

HCID 178429694HCID 178429694, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.7 kg of N-(4,5-bismethanesulfonyl-2-methylbenzoyl)guanidine are suspended in 25 l of ethanol at 60°, and 10.6 l of 1N HCl solution are added. On warming to 80°, a clear solution is obtained. The solution is allowed to cool slowly, with crystallisation beginning at 50°, The N-(4, 5-bismethanesulfonyl-2-methylbenzoyl)guanidine, hydrochloride obtained is subsequently dried to constant weight at 60°, giving N-(4,5-bismethanesulfonyl-2-methylbenzoyl)guanidine, hydrochloride.

Workup

  1. temperatureOn warming to 80°
  2. customa clear solution is obtained
  3. temperatureto cool slowly, with crystallisation
  4. custombeginning at 50°

Sources & evidence

ORD record
ord-c343834849234c048e271f9bf80076fc
Source dataset
uspto-grants-2004_01
Patent number
US06673968B1

Reaction notes

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