Piperidine → HCID 178518927, compound

HRID 1838776Notes

Reaction equation

HRID 1838776 reaction equation
Cl[C:2]1[C:7](Cl)=[CH:6][N:5]=[N:4][C:3]=1[OH:9].[NH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1>>[N:10]1([C:2]2[C:7]([N:10]3[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]3)=[CH:6][N:5]=[N:4][C:3]=2[OH:9])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 178518919HCID 178518919, compound

Product 1

HCID 178518927HCID 178518927, compoundYield 75%

Procedure

4,5-Dichloro-3-hydroxypyridazine (25.0 g; 0.151 mol) was dissolved in piperidine (120 mol), under reflux condition for 24 hours. After cooling, the deposited crystal was filtered, to give 4,5-dipiperidino-3-hydroxypyridazine in white crystal (30.3 g as a yield of 75%).

Workup

  1. temperatureunder reflux condition for 24 hours
  2. temperatureAfter cooling
  3. filtrationthe deposited crystal was filtered

Sources & evidence

ORD record
ord-661323e83da64554862a1abf172855a0
Source dataset
uspto-grants-2004_01
Patent number
US06676932B2

Reaction notes

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