Diisopropylethylamine → HCID 23449840, compound

HRID 1838805Notes

Reaction equation

HRID 1838805 reaction equation
C(OC([NH:8][CH2:9][CH2:10][N:11]([CH2:16][CH:17]([OH:28])[CH2:18][O:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[O:26][CH3:27])[C:12](=[O:15])[CH2:13]Cl)=O)(C)(C)C.C(N(C(C)C)CC)(C)C>C(O)(C(F)(F)F)=O>[OH:28][CH:17]([CH2:18][O:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[O:26][CH3:27])[CH2:16][N:11]1[CH2:10][CH2:9][NH:8][CH2:13][C:12]1=[O:15]

Participants

4

Reactant 2

HCID 81531DiisopropylethylamineHCID 23449825HCID 23449825, compound

Product 1

HCID 23449840HCID 23449840, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Compound 12 (0.5 g, 1.5 mmol) was dissolved in 10 mL TFA. The mixture was allowed to stir at RT for 2 h. TFA was removed under reduced pressure. The residue was dissolved in 20 mL EtOH and treated with diisopropylethyl amine (0.76 g, 4.5 mmol). The mixture was heated at reflux for 24 h. The solvent was removed under reduced pressure to afford compound 13 which was used without further purification.

Workup

  1. customTFA was removed under reduced pressure
  2. dissolutionThe residue was dissolved in 20 mL EtOH
  3. temperatureThe mixture was heated
  4. temperatureat reflux for 24 h
  5. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-a432d35661de4b8eb3dfd13a768aeacc
Source dataset
uspto-grants-2004_01
Patent number
US06677336B2

Reaction notes

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