Hydrochloric Acid → HCID 22648270, compound

HRID 1838809Notes

Reaction equation

HRID 1838809 reaction equation
[ClH:1].[CH3:2][C:3]1[S:4][C:5]2[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([NH2:15])[C:6]=2[N:16]=1.C(O)(C)C>CO>[ClH:1].[CH3:2][C:3]1[S:4][C:5]2[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([NH2:15])[C:6]=2[N:16]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 9815783HCID 9815783, compound

Product 1

HCID 22648270HCID 22648270, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Concentrated hydrochloric acid (0.2 mL of 12.1M) was added to a solution of 2-methylthiazolo[4,5-c]quinolin-4-amine (0.5 g) in methanol (15 mL). Isopropanol (15 mL) was added and then the reaction mixture was heated at reflux to remove the majority of the methanol. The resulting precipitate was isolated by filtration, washed with isopropanol and dried to provide 2-methylthiazolo[4,5-c]quinolin-4-amine hydrochloride as a solid, m.p. 323-325° C. Analysis: Calculated for C11H9N3S HCl: %C, 52.48; %H, 4.00; %N, 16.69; Found: %C, 52.46; %H, 4.08; %N, 16.52.

Workup

  1. temperaturethe reaction mixture was heated
  2. temperatureat reflux
  3. customto remove the majority of the methanol
  4. customThe resulting precipitate was isolated by filtration
  5. washwashed with isopropanol
  6. customdried

Sources & evidence

ORD record
ord-b1ee0e549a22424bbd0bf01e8d76177a
Source dataset
uspto-grants-2004_01
Patent number
US06677334B2

Reaction notes

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