Cyclohexanemethanol → HCID 5329590, compound

HRID 1838968Notes

Reaction equation

HRID 1838968 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH2:9][CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[C:5]([CH:16]=[O:17])=[C:4]([N:18](CC2C=CC(OC)=CC=2)CC2C=CC(OC)=CC=2)[N:3]=1.C1(CO)CCCCC1>FC(F)(F)C(O)=O>[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH2:9][CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[C:5]([CH:16]=[O:17])=[C:4]([NH2:18])[N:3]=1

Participants

4

Reactant 2

HCID 7507CyclohexanemethanolHCID 12986176HCID 12986176, compound

Product 1

HCID 5329590HCID 5329590, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

The mixture of 2-Amino-4-cyclohexylmethoxy-6-di(4-methoxybenzyl)amino-5-pyrimidine carbaldehyde and cyclohexylmethanol obtained previously was stirred in trifluoracetic acid (2 ml) at 65° C. for 24 h. The same workup procedure was used as previously, with purification of the product by column chromatography eluting with 40% EtOAc/petrol (40:60) yielding a pale yellow solid. M.p. 159-160° C.

Workup

  1. customobtained previously
  2. customwith purification of the product by column chromatography
  3. washeluting with 40% EtOAc/petrol (40:60)
  4. customyielding a pale yellow solid

Sources & evidence

ORD record
ord-5830df2929fe4bb082e30508b1470384
Source dataset
uspto-grants-2004_01
Patent number
US06677345B1

Reaction notes

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