Tert-Butylamine → HCID 69827556, compound

HRID 1839267Notes

Reaction equation

HRID 1839267 reaction equation
C([O:4][C@@H:5]1[C@H:9]([O:10]C(=O)C)[C@@H:8]([C:14]2[O:18][N:17]=[C:16]([Br:19])[CH:15]=2)[O:7][C@H:6]1[N:20]1[CH:28]=[N:27][C:26]2[C:21]1=[N:22][CH:23]=[N:24][C:25]=2[NH:29][C:30]1[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][C:31]=1[F:37])(=O)C.C(N)(C)(C)C>CO>[Br:19][C:16]1[CH:15]=[C:14]([C@@H:8]2[C@@H:9]([OH:10])[C@@H:5]([OH:4])[C@H:6]([N:20]3[CH:28]=[N:27][C:26]4[C:21]3=[N:22][CH:23]=[N:24][C:25]=4[NH:29][C:30]3[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][C:31]=3[F:37])[O:7]2)[O:18][N:17]=1

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 18336825HCID 18336825, compound

Product 1

HCID 69827556HCID 69827556, compoundYield 110.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(2R,3 R,4R,5S)-4-(acetyloxy)-5-(3-bromoisoxazol-5-yl)-2-[6-(4-chloro-2-fluoroanilino)-9H-purin-9-yl]tetrahydrofuran-3-yl acetate (16.8 mg) was treated with t-butylamine (0.08 ml) in methanol (0.8 ml) at 0° C. for 1.5 h, and the mixture was evaporated to dryness to give the title compound (16 mg).

Workup

  1. customthe mixture was evaporated to dryness

Sources & evidence

ORD record
ord-536c3427d02c4d8392e9dc37663469fc
Source dataset
uspto-grants-2004_01
Patent number
US06677316B2

Reaction notes

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