Methanol → HCID 23449059, compound

HRID 1839336Notes

Reaction equation

HRID 1839336 reaction equation
[CH:1]([C:3]1[N:4]=[CH:5][N:6]2[CH:10]=[CH:9][S:8][C:7]=12)=O.C1(P(=[CH:30][C:31]([O:33]C)=O)(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[CH3:35]O>>[O:33]=[C:31]([CH3:30])/[CH:35]=[CH:1]/[C:3]1[N:4]=[CH:5][N:6]2[CH:10]=[CH:9][S:8][C:7]=12

Participants

4

Reactant 3

HCID 887MethanolHCID 17453Acetic acid, 2-(triphenylphosphoranylidene)-, methyl esterHCID 22390357Imidazo(4,3-b)(1,3)thiazole-7-carbaldehyde

Product 1

HCID 23449059HCID 23449059, compound

Procedure

7-Formyl-imidazo[5,1-b]thiazole was dissolved in 15 ml of methanol. Methyl (triphenylphosphoranylidene)acetate (500 mg) was added to the solution. The mixture was stirred at room temperature for 15 min. The reaction solution was concentrated under the reduced pressure. The concentrate was purified by chromatography on silica gel to give 208 mg of 7-((E)-3-Oxo-1-buten-1-yl)imidazo[5,1-b]thiazole.

Workup

  1. concentrationThe reaction solution was concentrated under the reduced pressure
  2. customThe concentrate was purified by chromatography on silica gel

Sources & evidence

ORD record
ord-3dea4994371740419aa96727e987f950
Source dataset
uspto-grants-2004_01
Patent number
US06677331B2

Reaction notes

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