Acetaldehyde → 3-(1-Hydroxyethyl)-camphor

HRID 1839539Notes

Reaction equation

HRID 1839539 reaction equation
C(NC(C)C)(C)C.[C:8]12([CH3:18])[C:15]([CH3:17])([CH3:16])[CH:12]([CH2:13][CH2:14]1)[CH2:11][C:9]2=[O:10].[CH:19](=[O:21])[CH3:20].C(=O)([O-])O.[Na+]>C1COCC1.CCCCCC>[OH:21][CH:19]([CH:11]1[CH:12]2[C:15]([CH3:17])([CH3:16])[C:8]([CH3:18])([CH2:14][CH2:13]2)[C:9]1=[O:10])[CH3:20]

Participants

7

Reactant 4

HCID 177AcetaldehydeHCID 2537CamphorHCID 7912DiisopropylamineHCID 516892Sodium Bicarbonate

Product 1

HCID 147599003-(1-Hydroxyethyl)-camphorYield 80.1%

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolvent4×HCID 8058HexaneSolvent

Procedure

2.50 ml of 2.5 M n-butylithium hexane solution was added dropwise a tetrahydrofuran solution comprising 4 ml THF and 1.00 ml diisopropylamine at −78° C. and the mixture was stirred for 15 minutes. Then, a THF solution comprising 4 ml THF and 0.91 g camphor was added dropwise to the above solution at −78° C., then the solution was further admixed with 0.27 g of acetaldehyde and stirred for 15 minutes. This reaction solution was admixed with 50 ml of a saturated sodium hydrogen carbonate aqueous solution and restored to room temperature. The reaction product was extracted with diethylether. The organic layer was washed with saturated brine, dried with anhydrous sodium sulfate and then the solvent was removed under a vacuum. The residue was purified by means of silica gel column chromatography (eluent: hexane/ethylacetate=8/2) and 0.94 g of 3-(1-hydroxyethyl)-camphor was obtained (yield: 80%).

Workup

  1. customat −78° C.
  2. additionwas added dropwise to the above solution at −78° C.
  3. stirringstirred for 15 minutes
  4. customrestored to room temperature
  5. extractionThe reaction product was extracted with diethylether
  6. washThe organic layer was washed with saturated brine
  7. dry with materialdried with anhydrous sodium sulfate
  8. customthe solvent was removed under a vacuum
  9. customThe residue was purified by means of silica gel column chromatography (eluent: hexane/ethylacetate=8/2)

Sources & evidence

ORD record
ord-0c7d1886336f453c943d3a80d22616a8
Source dataset
uspto-grants-2004_01
Patent number
US06677384B1

Reaction notes

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