huagongshe.com
HRID1839664

反应详情

EQUATION

反应方程式

HRID 1839664 的结构方程式

REACTANTS

反应物

3
结构：CN(C)C=O
HCID6228

N,N-Dimethylformamide

C3H7NO

结构：O=P(Cl)(Cl)Cl
HCID24813

Phosphoric trichloride

Cl3OP

结构：CC(=O)N1CCC(C(=O)N2CCCCc3[nH]ccc32)CC1
HCID22561858

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)N1CCC(C(=O)N2CCCCc3[nH]c(C=O)cc32)CC1
HCID22561749

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：[Au]
催化剂HCID23985

Gold

Au

PROCEDURE

实验过程

1-[4-(5,6,7,8-Tetrahydro-1H-pyrrolo[3,2-b]azepine-4-carbonyl)-piperidin-1-yl]-ethanone (1.1 g) was formylated with POCl3 (186 μL, 1.2 eq.) and DMF using standard Vilsmierer condition to give 240 mg of 4-(1-acetyl-piperidine-4-carbonyl)-1,4,5,6,7,8-hexahydro-pyrrolo[3,2-b]azepine-2-carbaldehyde as a gold colored solid.