HRID1839828

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11

1,2-Dichloroethane

C2H4Cl2

HCID75771

1-Hydroxybenzotriazole

C6H5N3O

HCID20604768

未命名化合物

$结构：Cc1c(C(=O)O)c[nH]c1/C=C1\C(=O)Nc2cccc(-c3c(F)cccc3F)c21$

HCID60061429

未命名化合物

PRODUCTS

生成物

$结构：Cc1c(C(=O)NCC(O)CN2CCS(=O)(=O)CC2)c[nH]c1/C=C1\C(=O)Nc2cccc(-c3c(F)cccc3F)c21$

HCID60061401

未命名化合物

收率 60%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

5-[4-(2,6-Difluoro-phenyl)-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-4-methyl-1H-pyrrole-3-carboxylic acid (114 mg, 0.3 mmol) was coupled with 1-amino-3-(1,1-dioxo-1λ6-thiomorpholin-4-yl)-propan-2-ol (1.8 mmol), HOBt (1 eq.), EDC (1.5 eq.) and TEA (3 drops) in THF (1 mL), acetonitrile (1 mL) at rt for overnight to give 102 mg (60%) of the titled compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e465208edda6434986068316d87b2b41
来源数据集: uspto-grants-2004_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06677368B2
来源说明: uspto-grants-2004_01

反应 SMILES

[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1/[C:11](=[CH:19]/[C:20]1[NH:24][CH:23]=[C:22]([C:25](O)=[O:26])[C:21]=1[CH3:28])/[C:12](=[O:18])[NH:13]2.[NH2:29][CH2:30][CH:31]([OH:41])[CH2:32][N:33]1[CH2:38][CH2:37][S:36](=[O:40])(=[O:39])[CH2:35][CH2:34]1.C1C=CC2N(O)N=NC=2C=1.C(Cl)CCl>C1COCC1.C(#N)C>[O:40]=[S:36]1(=[O:39])[CH2:35][CH2:34][N:33]([CH2:32][CH:31]([OH:41])[CH2:30][NH:29][C:25]([C:22]2[C:21]([CH3:28])=[C:20](/[CH:19]=[C:11]3\[C:12](=[O:18])[NH:13][C:14]4[C:10]\3=[C:9]([C:3]3[C:4]([F:8])=[CH:5][CH:6]=[CH:7][C:2]=3[F:1])[CH:17]=[CH:16][CH:15]=4)[NH:24][CH:23]=2)=[O:26])[CH2:38][CH2:37]1