Hydrogen Peroxide → HCID 23450682, compound

HRID 1839876Notes

Reaction equation

HRID 1839876 reaction equation
[C:1]([C:4]1[C:5]([Cl:17])=[C:6]2[C:11](=[C:12]([CH3:14])[CH:13]=1)S[CH2:9][CH2:8][C:7]2([CH3:16])[CH3:15])(=[O:3])[CH3:2].OO.[S:20]([O-:23])(O)=[O:21].[Na+]>C(O)(=O)C>[C:1]([C:4]1[C:5]([Cl:17])=[C:6]2[C:11](=[C:12]([CH3:14])[CH:13]=1)[S:20](=[O:23])(=[O:21])[CH2:9][CH2:8][C:7]2([CH3:16])[CH3:15])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 23450668HCID 23450668, compoundHCID 23665763Sodium Bisulfite

Product 1

HCID 23450682HCID 23450682, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
80 °C

Procedure

5 ml of acetic acid was added to 3.0 g (11 mmol) of 6-acetyl-5-chloro-4,4,8-trimethylthiochroman, 3.7 g (33 mmol) of a 30% hydrogen peroxide aqueous solution was further added, and the mixture was heated at 80° C. for 2 hours. 20 ml of a 2% sodium hydrogensulfite was added to the reaction mixture, and a precipitated solid was recovered by filtration to give 2.8 g (yield 85%) of 6-acetyl-5-chloro-4,4,8-trimethylthiochroman-1,1-dioxide.

Workup

  1. additionwas further added
  2. filtrationa precipitated solid was recovered by filtration

Sources & evidence

ORD record
ord-9ab2b1db34834708844bad144d9407b4
Source dataset
uspto-grants-2004_01
Patent number
US06677460B1

Reaction notes

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