反应详情

温度

95 °C

A mixture of 6-chloro-2-oxindole (41 mg) (commercially available), indole-2-carbaldehyde (42 mg) (prepared according to Synthetic Communications, 1993, 23, 3109) and piperidine (1 drop) in ethanol (3 mL) was heated in a sealed tube at 95° C. for 3 hours. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in vacuum oven for overnight to give 62 mg (87% yield) of 6-chloro-3-(1H-indol-2-ylmethylene)-1,3-dihydro-indol-2-one as a shiny orange solid.

1. temperatureThe mixture was cooled to room temperature
2. filtrationThe solid was collected by vacuum filtration
3. washwashed with cold ethanol
4. customdried in vacuum oven for overnight