Hydrochloric Acid → HCID 23447403, compound

HRID 1840536Notes

Reaction equation

HRID 1840536 reaction equation
Cl.C(OC([NH:9][C:10]1[CH:37]=[CH:36][C:13]([CH2:14][N:15]2[CH2:20][CH2:19][N:18]([S:21]([C:24]3[CH:33]=[CH:32][C:31]4[C:26](=[CH:27][CH:28]=[C:29]([Cl:34])[CH:30]=4)[CH:25]=3)(=[O:23])=[O:22])[CH2:17][C:16]2=[O:35])=[CH:12][CH:11]=1)=O)(C)(C)C>C(OCC)(=O)C.CO>[ClH:34].[NH2:9][C:10]1[CH:37]=[CH:36][C:13]([CH2:14][N:15]2[CH2:20][CH2:19][N:18]([S:21]([C:24]3[CH:33]=[CH:32][C:31]4[C:26](=[CH:27][CH:28]=[C:29]([Cl:34])[CH:30]=4)[CH:25]=3)(=[O:22])=[O:23])[CH2:17][C:16]2=[O:35])=[CH:12][CH:11]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 23447476HCID 23447476, compound

Product 1

HCID 23447403HCID 23447403, compoundYield 196%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 4 N hydrochloric acid in ethyl acetate (10 ml) was added to a solution of 1-[4-(tert-butoxycarbonylamino)benzyl]-4-(6-chloronaphthalene-2-sulfonyl)-2-piperazinone (530 mg) in methanol (2 ml), and the mixture was stirred at room temperature for 3 hours. The reaction solution was concentrated, and the resulting crystals were filtered, washed with ethyl acetate-ether and dried to give the title compound (457 mg).

Workup

  1. concentrationThe reaction solution was concentrated
  2. filtrationthe resulting crystals were filtered
  3. washwashed with ethyl acetate-ether
  4. customdried

Sources & evidence

ORD record
ord-9be5d819b11849cca4784bb67a74267f
Source dataset
uspto-grants-2004_01
Patent number
US06680312B2

Reaction notes

Loading…