Hydrochloric Acid → HCID 23447328, compound

HRID 1840550Notes

Reaction equation

HRID 1840550 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([N:21]3[CH:25]=[CH:24][N:23]=[CH:22]3)=[CH:17][CH:16]=2)[C:10](=[O:26])[CH2:9]1)=O)(C)(C)C.[ClH:27]>CO.C(OCC)(=O)C>[ClH:27].[ClH:27].[N:21]1([C:18]2[CH:19]=[CH:20][C:15]([CH2:14][N:11]3[CH2:12][CH2:13][NH:8][CH2:9][C:10]3=[O:26])=[CH:16][CH:17]=2)[CH:25]=[CH:24][N:23]=[CH:22]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 23447292HCID 23447292, compound

Product 1

HCID 23447328HCID 23447328, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 4-(tert-butoxycarbonyl)-1-[4-(1H-imidazol-1-yl)benzyl]-2-piperazinone (1.5 g) in methanol (10 ml) was added 4N hydrochloric acid in ethyl acetate solution (50 ml), and the mixture was stirred at room temperature for 1 hour. The reaction solution was concentrated, and the residue was powdered with ethyl acetate, filtered and dried to give hygroscopic colorless solid of the title compound (1.12 g).

Workup

  1. concentrationThe reaction solution was concentrated
  2. filtrationfiltered
  3. customdried

Sources & evidence

ORD record
ord-65c85e78d7564966b22daaea052fa985
Source dataset
uspto-grants-2004_01
Patent number
US06680312B2

Reaction notes

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