反应详情

温度

70 °C

A mixture of 4-[4-(bromomethyl)benzenesulfonyl]-1-[1-(tert-butoxycarbonyl)piperidin-4-ylmethyl]-2-piperazinone (430 mg), potassium carbonate (112 mg) and imidazole (83 mg) in DMF (15 ml) was stirred at 70° C. for 1 hour. The reaction solution was concentrated, and to the residue was added water. The mixture was extracted with ethyl acetate, washed with water, sodium bicarbonate solution and brine, dried and concentrated, and the residue was recrystallized from ethyl acetate/hexane to give colorless crystals of 4-[4-(1H-imidazol-1-ylmethyl)benzenesulfonyl]-1-[1-(tert-butoxycarbonyl)piperidin-4-ylmethyl]-2-piperazinone (421 mg).

1. concentrationThe reaction solution was concentrated
2. additionto the residue was added water
3. extractionThe mixture was extracted with ethyl acetate
4. washwashed with water, sodium bicarbonate solution and brine
5. customdried
6. concentrationconcentrated
7. customthe residue was recrystallized from ethyl acetate/hexane